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The Beginning of Dermacosmetics

Dermacosmetics
A term combining Dermatology and Cosmetics, referring to skincare developed based on dermatological research, clinical data, and a science-driven approach to skin concerns.

Dermacosmetics began with skincare rooted in dermatology and designed to address specific skin concerns.

In the early days, products were developed mainly through dermatology channels, focusing on soothing and moisturizing sensitive skin and supporting skin recovery.

Over time, the category moved beyond professional channels and expanded into everyday skincare.

Today, dermacosmetics has become a mainstream category for maintaining healthier-looking sensitive and easily irritated skin.

Dermacosmetics Are Evolving

Today, dermacosmetics is expanding into new areas —
from recovery care using EGF and PDRN,
to Skin Longevity focused on mitochondria and biological aging,
and even Senolytics targeting senescent cells.

So, where is dermacosmetics heading next?

Let’s explore the key concepts worth watching —
along with ingredient solutions from COSEEDBIOPHARM.

EGF: A Key Driver of Skin Recovery

Protecting the skin matters,
but how well it recovers after damage matters just as much.

EGF is a representative growth factor involved in the proliferation and migration of epidermal cells, helping support the skin’s recovery process.

Stanley Cohen, who discovered EGF, was awarded the 1986 Nobel Prize in Physiology or Medicine for his work on growth factors.

EGF (Epidermal Growth Factor)
A naturally occurring protein growth factor that promotes epidermal cell proliferation and supports skin regeneration and barrier recovery.

What Should You Look for in EGF?

For EGF to work effectively in skin applications,
it is important to verify its biological activity, purity, and delivery stability.

COSEEDBIOPHARM’s EGF has a protein sequence 100% identical to human EGF.

Liposome technology enhances skin delivery, while recombinant production enables high-purity and consistent EGF production.

INCI
sh-Oligopeptide-1

100% Sequence Identity to Human EGF
N-terminal sequencing, HPLC, and LC-MS analysis confirmed that the amino acid sequence and structural characteristics are identical to human EGF.

2.6× Higher Biological Activity vs. Standard
External activity testing showed an ED50 of 0.28 ng/mL, demonstrating approximately 2.6 times greater biological activity than the R&D Systems standard.

Recombinant High-Purity Protein
EGF is produced using recombinant technology and purified through controlled separation and purification processes for consistent, high-purity production.

147.2 nm Liposome Technology
Liposome technology was applied to protect EGF activity and improve skin delivery. The mean particle size was confirmed at 147.2 nm, while ex-vivo testing showed increasing skin penetration over time.

Skin Aging, Now Viewed at the Cellular Level

Skin aging is no longer just about reducing wrinkles or improving firmness.

Increasing attention is being paid to how long the skin can maintain healthy functions.

As we age, senescent cells that no longer perform their normal functions gradually accumulate.

Senolytics is an emerging strategy that selectively targets these senescent cells to help maintain a healthier cellular environment.

Longevity
An aging research concept that goes beyond simply extending lifespan, focusing instead on maintaining healthy function and condition for longer.

Senescent Cells
Cells that accumulate over time and can influence tissue dysfunction and the development of an aging cellular environment.

Senolytics
A strategy designed to selectively remove accumulated senescent cells and reduce their impact on inflammation and tissue function.

Fisenolyme Targets Senescent Cells

The key to senolytics is not targeting healthy cells,
but precisely targeting senescent cells.

Fisenolyme reduced p21, a marker associated with cellular senescence, and activated Caspase-8, a signal involved in apoptosis, demonstrating its potential to selectively target senescent cells.

INCI
Citrus Aurantifolia (Lime) Fruit Extract

1,000 ppm Fisetin
Contains 1,000 ppm of Fisetin, a lime-derived flavonoid used as a marker compound.

Approx. 43% Reduction in Senescent Cells (p21+)
Following Fisenolyme treatment, the proportion of p21-positive senescent cells decreased from 66% to 37.5%.

Approx. 26× Increase in Caspase-8
Caspase-8 signaling associated with the apoptotic pathway increased approximately 26-fold compared with the control.

Selective Targeting of Senescent Cells
Caspase-8 apoptotic signals were observed in approximately 90% of p21-positive senescent cells, indicating selective targeting of senescent cells.

 

Delivering the Longevity Protein into Skin — PTD-Sirtuin6

Sirtuin6 is a key longevity-associated protein in the sirtuin family, involved in DNA repair and the regulation of aging.

COSEEDBIOPHARM applied PTD delivery technology to a protein sequence 100% identical to human Sirtuin6, developing PTD-Sirt6 to overcome the limitations of skin delivery.

INCI
sh-Polypeptide-138

100% Sequence Identity to Human SIRTUIN6
NCBI BLAST analysis confirmed 100% protein sequence identity with human Sirtuin6.

PTD Skin Delivery Technology
While conventional Sirt6 showed no detectable skin penetration, PTD-Sirt6 demonstrated penetration rates of 48% in keratinocytes and 40% in fibroblasts.

Reduction of Aging Markers p21 and p16
In senescence-induced cells, PTD-Sirt6 reduced p21 by 77.5% and p16 by 70.6%.

79.88% Increase in Collagen Type I
PTD-Sirt6 increased the expression of Collagen Type I, a major structural protein of the human dermis, by 79.88% compared with the untreated control.

The Right Approach for the Right Skin

For sensitive skin: barrier care and soothing.
For damaged skin: recovery and growth factors.
For aging skin: senolytics and longevity.

Even within dermacosmetics,
the right approach can differ depending on the skin change you want to address.

If you are looking for the right approach to a specific skin concern,
COSEEDBIOPHARM can help you find the solution.